Skeletal Editing: Interconversion of Arenes and Heteroarenes
WEBJan 13, 2023 · Skeletal editing involves making specific point-changes to the core of a molecule through the selective insertion, deletion or exchange of atoms.
Skeletal editing through direct nitrogen deletion of secondary ... - Nature
WEBMay 12, 2021 · Molecular editing and late-stage functionalization have emerged as appealing strategies for the identification of such ‘missing’ transformations 4, 5, 6, 7, and represent the ideals of modern...
Molecular Skeleton Editing for New Drug Discovery
WEBAug 12, 2024 · Single-atom skeleton editing, particularly the carbon-to-nitrogen transmutation in an aromatic ring, has proven to be a more challenging approach for modifying the molecular core structure.
Skeletal editing of pyridines through atom-pair swap from CN to …
WEBJan 18, 2024 · Skeletal editing is a straightforward synthetic strategy for precise substitution or rearrangement of atoms in core ring structures of complex molecules; it enables quick...
‘Almost magical’: chemists can now move single atoms in and out …
WEBMay 31, 2023 · An explosion of skeletal editing methods to insert, delete or swap individual atoms in molecular backbones could accelerate drug discovery.
Late-stage diversification of indole skeletons through ... - Science
WEBSep 1, 2022 · Herein, we report the skeletal editing of indoles through nitrogen atom insertion, accessing the corresponding quinazoline or quinoxaline bioisosteres by trapping of an electrophilic nitrene species generated from …
Skeletal Editing—Nitrogen Deletion of ... - Wiley Online Library
WEBAug 1, 2021 · Single-atom N-deletion is a novel approach for constructing C−C bonds under N 2 extrusion and uses widely available secondary amines in late-stage skeletal modification enabling ring contraction and structure …
WEBMolecular skeleton editing refers to structural remodeling and represents an appealing editing strategy due to the capability of rapidly building onto, changing, or pruning molecules (Figure 1A).
Skeletal Editing: Ring Insertion for Direct Access to Heterocycles
WEBApr 23, 2024 · Skeleton editing has rapidly advanced as a synthetic methodology in recent years, significantly streamlining the synthesis process and gaining widespread acceptance in drug synthesis and development. This field encompasses diverse ring reactions, many of which exhibit immense potential in skeleton e ….
Skeletal Editing: Ring Insertion for Direct Access to Heterocycles
WEBApr 7, 2024 · Skeleton editing, as a direct synthesis method, involves precisely substituting or rearranging atoms within the core ring structure of complex molecules [18,19]. It includes various reaction types, such as single-atom, double-atom, multi-atom, and ring modifications, focusing on altering ring systems . Each modification type involves a wide ...
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