Mount Mitchell is the highest peak of the Appalachian Mountains and the highest peak in mainland North America east of the Mississippi River. It is located near Burnsville in Yancey County, North Carolina in the Black Mountain subrange of the Appalachians about 19 miles northeast of Asheville. It is protected by Mount Mitchell State Park and surroundeā¦Mount Mitchell is the highest peak of the Appalachian Mountains and the highest peak in mainland North America east of the Mississippi River. It is located near Burnsville in Yancey County, North Carolina in the Black Mountain subrange of the Appalachians about 19 miles northeast of Asheville. It is protected by Mount Mitchell State Park and surrounded by the Pisgah National Forest. Mount Mitchell's elevation is 6,684 feet above sea level. Mount Mitchell is ranked 31st by topographic isolation.