Iran's supreme leader, Ayatollah Ali Khamenei, has weathered a series of challenges but Israel's unprecedented strikes mark his most serious crisis yet, threatening both the clerical system he leads and his own physical survival.

Iran unleashed a missile barrage on Israeli cities Monday after Israeli strikes deep inside the Islamic republic, leaving streets in ruins and the death toll in Israel climbing by 11 amid a spiralling air war.

Iran's president, Masoud Pezeshkian, calls for unity among citizens as the country faces escalating conflict with Israel, urging them to set aside differences in the face of 'genocidal criminal aggression'.

The deadly conflict between Israel and Iran has entered a fourth day, with both sides firing waves of missiles overnight. Follow for live updates.

JERUSALEM/DUBAI/WASHINGTON (Reuters) - At least 20 senior Iranian commanders including the head of the revolutionary guards, Aerospace Force Commander Amir Ali Hajizadeh, were killed in Israel's strikes on Iran on Friday, two regional sources told Reuters.

Unsafe: In another public safety incident, an iron bridge collapsed at a popular tourist spot in Maharashtra’s Pune district, killing at least four persons, including a child, and injuring 38 others. The local administration has set up a panel to investigate the matter and whether a structural audit of the bridge was conducted.

Iran's Revolutionary Guard said it launched ballistic missiles at Israel - and the IDF claimed some were intercepted - as the country's supreme leader vowed to "inflict heavy blows" in retaliation for Israel's strikes the previous day

D-Day has arrived for Israel and Iran. After years of covert warfare, cyberattacks, and clandestine operations, Israel has taken the initiative. In the early hours of Friday, June 13, it launched a direct assault on the heart of Iran’s nuclear program.

Prime Minister Shehbaz Sharif spoke with Iranian President Masoud Pezeshkian, expressing Pakistan’s unwavering solidarity with Iran after Israel’s attacks, which he described as “blatant provocations”.

Meanwhile Israel has continued targeting Iran, with Iranian media reporting at least 128 people have been killed, citing the country's health ministry.