The San Francisco 49ers are playing the Tennessee Titans on Sunday, but they could benefit from some other games going certain ways.

Brandon Aiyuk hasn't played an NFL game since his serious knee injury in 2024. Here's why he won't be playing at all in 2025.

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

The Athletic's Dianna Russini is expecting an answer in the near future as to whether Brandon Aiyuk will play another game for the San Francisco 49ers.

Aiyuk, 27, has not played a down of football since injuring his ACL and MCL in the 49ers' 28–18 loss to the Chiefs in Week 7 last year. Since then, the gifted receiver's tenure with San Francisco has taken multiple turns.

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4:25 p.m. ET.

The Tennessee Titans and San Francisco 49ers face off in Week 15 action this Sunday at Levi's Stadium. Literally no one expects the Titans to win this game, and it's unlikely the Titans can keep the score close. The 49ers are in the playoff hunt and will be fresh off their bye week, while the Titans are on a different trajectory.

Need to know. Brock off a bye. 49ers quarterback Brock Purdy has played two games off a bye in his career, and he has been nearly perfect in both. In those two g

The San Francisco 49ers are sitting at 9-4 with four weeks left in what has been quite the season this year. They’ve dealt with injuries, another wide receiver saga, and still have managed to be in the playoff picture despite playing a number of first and second-year players this season.