Treosulfan (L-threitol-1,4-dimethanesulfonate) is a prodrug of a bifunctional alkylating agent with a structure similar to BU, but it demonstrates less organ toxicity than BU. The monoepoxybutane and ...
Cl = total body clearance; CV = coefficient of variation; F = bioavailability; Ka = absorption constant; PPV = population parameter variability (interindividual variability in parameter expressed as a ...
Second cancers after pediatric Hodgkin's disease. The relationship between pretreatment characteristics and the effects of epirubicin were investigated in 20 chemotherapy-naive patients. Measurements ...
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