We report a case of paraneoplastic cerebellar degeneration (PCD) associated with adenocarcinoma of the esophagus and anti-Yo antibodies in a male patient. The patient presented with progressive ataxia ...

Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional ...

Alcoholic cerebellar degeneration may slowly evolve or have relatively sudden onset, as in this case. Movement disorders associated with alcoholic cerebellar degeneration include cerebellar ataxia, ...

Neurexin, a cell associated with neurodevelopmental disorders, is an essential molecule for the survival of nerve cells called cerebellar granule cells in the cerebellum. This study revealed that ...

Researchers have developed an animal model that reproduces motor dysfunction and cerebellar neurodegeneration similar to that in spinocerebellar ataxia (SCA) by inhibiting chaperone-mediated autophagy ...

What is causing this 55-year-old woman to have distorted speech and balance problems when walking, and why have her symptoms worsened progressively since they came on 14 years ago? Those are the ...

Cerebellar ataxia results from dysfunction of the cerebellum, which is part of the brain that helps regulate and control movement and balance. People may experience changes in gait, speech, and eye ...

With a look of determination on his face, 5-year-old Camden Hanson, who lives with a brain condition that affects his ability to move, took his first steps on Saturday and celebrated with his proud ...

Spinal muscular atrophy is a rare genetic disease of the nerve cells in the spinal cord that can appear as early as infancy. The disease leads to a progressive loss of muscle strength. Those affected ...

In 1504, Leonardo da Vinci made wax castings of the human brain and coined the term cerebellum (Latin for “little brain”). Historically, the cerebellum has been considered by most neuroscientists to ...