Nature

Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation

Addiction is an ongoing public health crisis, with opioids and cocaine leading the list of drugs responsible for overdose deaths in the United States. Notably, from 2015 to 2021, there was a 2.5-fold ...
Psychology Today

Cocaine Use Is on the Rise

This post is in response to Which Drug Epidemic Is Next: Meth, Psychedelics, Mushrooms? By Mark S. Gold M.D. Cocaine use is increasingly prevalent among high-achieving professionals. Source: Image ...
Nature

The role of the prelimbic cortex to nucleus accumbens core projection in the reinstatement of cocaine-seeking after cocaine-alcohol polysubstance use

Cocaine use disorder (CUD) is a chronic, relapsing disorder that affects over one million people in the United States. Rodent models of cocaine use disorder are critical for identifying ...
Science Daily

Continued cocaine use disrupts communication between major brain networks

New research provides new insights into the brain processes underlying cocaine addiction. The findings are crucial for developing new therapeutics and identifying an imaging marker for cocaine use ...