Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

An innovative CRISPR-Cas12f-based activator system may hold significant potential in the future of gene therapy and biological research, suggest researchers of a new study. The study highlights the ...

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...

A figure from the paper illustates a key finding of "compromised compartmentalization": chromatin that was locking genes down in health became more open in Alzheimer's, while chromatin that was open ...

Turning genes on and off is like flipping a light switch, controlling whether genes in a cell are active. When a gene is turned on, the production of proteins or other substances is promoted; when ...