Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known as post-translational modifications, or PTMs, these can change how a ...

Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...

New York, NY — [June 3, 2026] —Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward ...

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs. In recent years, models like ...

In a recent paper in ACS Central Science, researchers report a strategy for targeting covalent modifications to specific sites on proteins. The modifier molecules use an antibody to target a protein ...

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition ...

Located at the cellular interface, membrane proteins play critical regulatory roles in the signaling between a cell and its interacting environment, making them popular and ideal drug targets.

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...

This voice experience is generated by AI. Learn more. This voice experience is generated by AI. Learn more. Researchers at the Canadian Light Source have discovered a molecular glue that can bind two ...

Light chain amyloidosis is not cancer, but cancer drugs are this rare disease’s standard of care. The patient need for new treatment options has sparked R&D efforts at biotech and big pharmaceutical ...