Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

About Nuvectis Pharma, Inc. Nuvectis Pharma, Inc. is a biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical ...

Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong-Dong Wang, Hongjian Jin, Yiping Fan, Patrick ...

Leishmaniasis belongs to the class of neglected tropical diseases (NTDs) that particularly affect people in the poorest ...

Pulmonary fibrosis is a deadly disease in which the lungs become thickened and scarred, gradually losing their ability to ...

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...

This is a preview. Log in through your library . Abstract Drought stress seriously limits crop productivity. Although studies have been carried out, it is still largely unknown how plants respond to ...

Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. COQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone. A new collaborative study ...

FMC-242 is a potentially best-in-class covalent allosteric inhibitor that breaks the interaction between PI3Kα and RAS, ...