RNA molecules can be modified by enzymes through the addition or removal of chemical groups, but the roles of these modifications in the regulation of both mRNAs and non-coding RNAs are not fully ...

Long known as a messenger within cells, RNA is increasingly seen as life’s molecular communication system — even between organisms widely separated by evolution. For a molecule of RNA, the world is a ...

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators. The ...

Using a novel method, Weizmann Institute of Science researchers map 16 types of simultaneous changes in dozens of samples; ...

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A ...

The original version of this story appeared in Quanta Magazine. For a molecule of RNA, the world is a dangerous place. Unlike DNA, which can persist for millions of years in its remarkably stable, ...

CRISPR-Cas13, a powerful RNA-targeting technology is gaining increasing attention as a next-generation gene therapy platform due to its precision and reduced side effects. Utilizing this system, ...

Researchers have developed a powerful tool capable of scanning thousands of biological samples to detect transfer ribonucleic acid (tRNA) modifications—tiny chemical changes to RNA molecules that help ...

RNA plays critical roles in nearly all biological processes, but current methods for sequencing RNA are significantly limited. This is partially because RNA molecules are chemically modified within ...

Oceans churned with lava. Air filled thick with smoke. Asteroids stormed down incessantly. Life during the Hadean Eon four billion years ago was a struggle, and yet that was when it began. 1,2 With no ...

Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to ...