Riboswitches are structured noncoding RNA elements that modulate gene expression by sensing small-molecule ligands and undergoing conformational changes. They consist of two principal regions: an ...
RNAs can begin to fold immediately as they emerge from RNA polymerase. During cotranscriptional folding, interactions between nascent RNAs and ligands are able to direct the formation of alternative ...
How active compounds affect RNA and thus the expression of genes is of great interest for the development of potential therapeutics. Innsbruck chemists have now used a method they recently developed ...
Scientific discoveries come through many different means. Breakthroughs can result from purposefully-executed research projects that are perhaps punctuated with unexpected flashes of insight. In rare ...
In work with implications for functional studies and drug discovery, researchers have identified aptamer ligands (short folded RNAs) capable of distinguishing between on and off states of messenger ...
Scientists have shed new light on a molecular switch that turns genes on or off in response to a cell's energy needs. Scientists from The Scripps Research Institute have shed new light on a molecular ...
To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics. A promising target for new and improved ...
This kind of complex signaling had long been thought to be the domain of just proteins. A team of researchers at The Scripps Research Institute has found that RNA riboswitches respond simultaneously ...
Although one might think it would be simple, the genetics of bacteria can be rather complicated. A bacterium’s genes use a set of regulatory proteins and other molecules to monitor and change genetic ...
One of the central tenets of biology is that information flows from DNA to RNA in order to encode proteins, which function in the cell. Arguably just as critical as the genetic code is the timing of ...
LA JOLLA, CA - Scientists from The Scripps Research Institute have shed new light on a molecular switch that turns genes on or off in response to a cell's energy needs. The study-published February 13 ...
Rice University biochemist Edward Nikonowicz has been awarded a National Institutes of Health grant to study a gene regulation mechanism that may someday be exploited to help fight bacterial ...
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