The field of radioligand therapy has advanced greatly in recent years, driven largely by β-emitting therapies targeting somatostatin receptor–expressing tumors and the prostate-specific membrane ...

Protein tyrosine kinase-7 (PTK7), a member of receptor tyrosine kinase superfamily initially identified as colon carcinoma kinase-4, is highly expressed in various human malignancies. Its expression ...

Acute myocardial infarction is conventionally viewed as a focal disease of the heart, where the principal damage is incurred. However, increasingly appreciated is the fact that body systems do not ...

Chimeric antigen receptor T-cell (CAR T) therapy has shown remarkable efficacy in treating relapsed or refractory large B-cell lymphoma. However, for nearly half of these patients, the therapy ...

AMG 110, a bispecific T cell engager (BiTE) antibody construct, induces T cell–mediated cancer cell death by cross-linking epithelial cell adhesion molecule (EpCAM) on tumor cells with a cluster of ...

Targeted diagnosis and therapy enable precise tumor detection and treatment. Successful examples for precise tumor targeting are diagnostic and therapeutic radioligands. However, patients with tumors ...

Tumor-specific targeting ligands were recently exploited to deliver both imaging and therapeutic agents selectively to cancer tissues in vivo. Because the cholecystokinin 2 receptor (CCK2R) is ...

In this issue of The Journal of Nuclear Medicine, Rowe et al. describe application of the centiloid methodology for scaling and analysis of studies performed with 18F-NAV4694 for characterizing ...

Clinical molecular imaging with PET has an evolving role in the diagnosis and treatment of left ventricular assist device (LVAD)–specific infection. We analyzed the added value of parametric ...

Because γ cameras are generally susceptible to environmental conditions and system vulnerabilities, they require routine evaluation of uniformity performance. The metrics for such evaluations are ...

SPECT is a rapidly changing field, and the past several years have produced new developments in both hardware technology and image-processing algorithms. At the component level there have been ...

In recent years, several new radiotracers and radionuclide therapies have been developed. There is a renaissance in nuclear medicine and molecular imaging today in terms of, for example, the ability ...