The San Francisco 49ers (9-4) will face the Tennessee Titans (2-11) in Week 15 at Levi’s Stadium, with all eyes on star running back Christian McCaffrey. McCaffrey was a late addition to the injury report on Saturday with a back issue, earning a questionable designation.

The San Francisco 49ers are playing the Tennessee Titans on Sunday, but they could benefit from some other games going certain ways.

The San Francisco 49ers made a significant decision on wide receiver Brandon Aiyuk that could spell the end of his tenure in the Bay Area.

See where the San Francisco 49ers stand in Week 15 power rankings as the team comes off its bye week, riding a three-game win streak.

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

Brandon Aiyuk hasn't played an NFL game since his serious knee injury in 2024. Here's why he won't be playing at all in 2025.

RB Christian McCaffrey is expected to play vs. the Titans despite a questionable tag, with multiple NFL insiders signaling good news.

The San Francisco 49ers could face a major setback when the 2025 NFL season ends, as Robert Saleh might be on a team's radar for head coach.