A 41 year old man presented with an eight year history of paroxysmal attacks of chest pain, palpitations, excessive sweating, nausea, headache, and pallor. Six years previously he had undergone ...

Background Cancer survivors have an increased risk of heart failure, but this is balanced by the risk of death from other ...

The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. Far from being inert, it is metabolically active and produces a variety of vasoactive ...

Background Heart auscultation is a widely used and cost-effective clinical tool for detecting valvular heart disease (VHD), ...

Background Chronic kidney disease is common in patients with coronary artery disease (CAD) and can significantly affect drug excretion and efficacy. This study focuses on the effects of modification ...

Background Heterogeneity of heart failure with preserved ejection fraction (HFpEF) results in significant challenges for treatment development. Identifying and characterising distinct HFpEF ...

Cardiac rhythm during sleep is influenced by the autonomic nervous system and various pathologic states. Most arrhythmias that occur during sleep are detected incidentally on Holter recordings, and ...

Background Current risk scores inadequately predict long-term mortality after transcatheter aortic valve replacement (TAVR), ...

Currently, most international guidelines advocate for risk stratification of acute pulmonary embolism (PE) as a framework to guide treatment decisions. Key prognostic factors for patients with PE ...

Introduction Growing numbers of public access defibrillators aim to improve the effectiveness of bystander cardiopulmonary resuscitation prior to ambulance arrival. In the UK, however, public access ...