This mouse model of ALS overexpresses wild-type human TARDBP (TDP-43) in postnatal neurons. Mice in this line, called TAR4, develop ALS-related phenotypes, including severe motor impairment, loss of ...
News Peptide Brace Against AD—Insulin, Neuropeptide Y Tame Aβ Toxicity 10 Feb 2009 Aβ and Phospho-tau: Strange Bedfellows Get Intimate at Synapses 19 Sep 2008 The Skinny on FAT: APP’s Role in Fast ...
Amyloid-related imaging abnormalities, aka ARIA, are red flags on MRI scans. They alert clinicians that a patient on lecanemab or donanemab may be in danger. Yet early signs of ARIA can be subtle and ...
R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. This knock-in rat model carries the R47H mutation in the rat Trem2 gene and a humanized Aβ ...
The purpose of this notice is to inform potential applicants of a change in the key dates for notice of funding opportunity (NOFO) RFA-NS-25-017, BRAIN Initiative: Optimization of Instrumentation and ...
To create this model, an adeno-associated viral (AAV) vector encoding human tau with the P301L mutation was injected into the ventricles of neonatal mice. At 6 months of age, Tau P301L-AAV mice ...
Terry Suk, B.Sc., Ph.D.
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