Amyloid-related imaging abnormalities, aka ARIA, are red flags on MRI scans. They alert clinicians that a patient on lecanemab or donanemab may be in danger. Yet early signs of ARIA can be subtle and ...
Terry Suk, B.Sc., Ph.D.
Scientists have attempted to bolster microglia in the Alzheimer’s brain by switching on TREM2 signaling, but so far, these efforts have met with little success. Might it work better to bypass TREM2 by ...
In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people. Current microglial PET tracers target the mitochondrial transporter TSPO, but ...
Mounting evidence links infections to a greater risk of dementia, and vaccination to neuroprotection. What underlies this relationship? In a preprint posted to Research Square on January 13, ...
This database is a repository of normal genetic variability, designed to be a tool for researchers who study neurodegenerative disease. It contains whole-exome sequencing results from nearly 500 ...
How prevalent is Alzheimer’s disease neuropathological change (ADNC), namely amyloid plaques and neurofibrillary tangles? Until recently, estimates among living people relied on CSF biomarkers or PET ...
According to a recent study, the view that Alzheimer’s disease damages the brain irreversibly might need to change. In December 22 Cell Reports Medicine online, scientists led by Andrew Pieper of Case ...
On November 24, Novo Nordisk announced that the GLP-1 mimetic semaglutide had failed to slow progression of Alzheimer’s disease in two Phase 3 trials. Even though the cat was out of the bag, ...
Transferrin-receptor shuttles distribute antibody cargo throughout the parenchyma, steering clear of ARIA-provoking vascular amyloid. Trontinemab is enrolling Phase 3 for early AD, announces plans for ...
Common variants in the phosphoinositol phosphatase INPP5D are linked to an increased risk of late-onset Alzheimer’s disease, but no one is quite sure why. Recent work suggests that depleting INPP5D in ...
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