Oncogene - Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas Skip to main content Thank you for visiting nature.com.

The proto-oncogene c-Fos serves as a critical marker of neuronal activation, rapidly induced in response to novel stimuli and playing a pivotal role in learning and memory through pathways such as ...

c-Fos activation during learning involves glutamate signaling, ... Oxidative stress in AD activates MAPK pathways, upregulating c-Fos and disrupting mitochondrial function.

The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a ...

Aberrations of signaling pathways induced by oncogenic events, such as activation of EGFR, MAPK, or PI3K–Akt pathways, 53 and elevated expression of STAT3 and HIF-1 transcription factors 54,55 ...