New research has identified the gene Egr-1 as a critical regulator of immune balance, offering hope for autoimmune disease therapies.

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen ...

Plant phototropism—directional growth in response to light—serves as a key adaptive mechanism, optimizing photosynthesis and ...

Dopamine doesn’t flood the brain as once believed – it fires in exact, ultra-fast bursts that target specific neurons. The ...

Although commitment of mesenchyme precursors to the osteochondrogenic lineages requires both Wnt and bone morphogenetic protein signaling, the canonical Wnt pathway subsequently acts as the master ...

c-Fos exhibits a dual role: supporting memory in healthy brains and driving neurodegeneration in AD. Its dysregulation in AD involves multiple pathways, including Aβ toxicity, apoptosis, and ...

Neural activity in healthy brain releases glutamate which binds to synaptic receptors and activates Ca ++ influx and further signaling pathways of CAM/ERK/MAPK/CREB in neurons. CREB elevation ...

Formononetin Attenuates Osteoclastogenesis via Suppressing the RANKL-Induced Activation of NF-κB, c-Fos, and Nuclear Factor of Activated T-Cells Cytoplasmic 1 Signaling Pathway ...

This study showed that miR-335-3p expression was simultaneously reduced in murine NAC, serum, and bone under psychological stress. The miR-335-3p/Fos/NFATC1 signaling pathway was validated in ...

Moreover, miR-335-3p, which can inhibit Fos translation and its integration with Nftac1, is significantly reduced under psychological stress and sequentially enhances the activation of NFATC1 ...

Involvement of the ERK Signaling Pathway in Fisetin Reduces Invasion and Migration in the Human Lung Cancer Cell Line A549. Journal of Agricultural and Food Chemistry2009,57 (19) , 8933-8941.