TYK2 restricts the metastasis of colorectal tumors to the liver by supporting dendritic cell-dependent induction of antitumor CD8+ T cells, which could impact the use of TYK2 inhibitors in patients.
Abstract. Multiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. Here, we investigated multiplexed histological images of ...
Mitochondrial glutathione import via SLC25A39 supports breast cancer metastasis by linking glutathione availability to ATF4-driven integrated stress response signaling during early metastatic ...
Cancer Discov (2025) 15 (12): 2422–2430.
1Yeungnam University, College of Medicine, Department of Pathology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, ...
1Department of Biological Sciences, New York City College of Technology, City University of New York, Brooklyn, New York. 2Biology and Computer PhD Programs, The CUNY Graduate Center, City University ...
Aptabio Therapeutics Inc., Yongin, Republic of Korea.
The combination of anti-TROP2 ADCs with PD-(L)1 inhibitors represents a promising therapeutic strategy, merging targeted therapy with immunotherapy to improve treatment outcomes. Clinical trials are ...
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Affinity Biopharmaceutical Co., Ltd., Shanghai, China.
Integrins are a large family of cell surface receptors with diverse roles in cellular adhesion, motility, and cytokinesis. Functional integrins exist as heterodimers consisting of single alpha and ...
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