The Hard Truth Benzos Are the Real Long-Term Risk When patients come to me, I always slow them down and explain that the medication with the most serious long-term impact on dependence, the central nervous system, and withdrawal is the benzodiazepine benzodiazepines. Trying to taper Suboxone Suboxone first often backfires — people almost always end up needing more benzos to get through those early stages. And using benzos to get off Suboxone simply doesn’t make sense physiologically or clinicall