Can hormones calm your mast cells… or make them more reactive? For patients with MCAS, the answer isn’t one-size-fits-all. Hormone replacement therapy can be incredibly helpful for some individuals, but only when it’s carefully tailored to maintain stability. Estrogen and progesterone directly influence mast-cell behavior. Sudden shifts can provoke symptoms, while steady, physiologic hormone levels may actually support immune regulation and reduce reactivity. With the FDA recently removing the b
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